Panama City 5-star Hotels
Compare rates for 5-star hotels in Panama City, Panama from hundreds of popular travel sites on HotelsCombined.
Panama City, Panama
2 May — 3 May2
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Travel insights for hotels in Panama City
Use these up-to-date, data-driven insights about booking a hotel in Panama City including ideal times to book, pricing trends, and more.
What is the cheapest month to book a hotel in Panama City?
The cheapest month to book a hotel in Panama City is September (C$ 251). Conversely, the most expensive month to stay in Panama City is January (C$ 415).
What is the cheapest day to stay in a hotel in Panama City?
The cheapest day to stay in Panama City is Wednesday (C$ 275). On the other hand, travelers can expect to pay the most on Tuesday, when the average nightly price is C$ 386.
How much is a hotel in Panama City tonight?
Users have found prices for hotels in Panama City tonight starting as low as C$ 24, rising to an average cost of C$ 173, based on searches in the last 72 hours. Prices start from C$ 61 for a 4-star hotel in Panama City for tonight.
How much is a Panama City hotel room this weekend?
In the past 72 hours, we’ve seen prices for hotels in Panama City this weekend for as little as C$ 25/night. If you’re specifically looking for a 3-star hotel this weekend, our users have found prices as low as C$ 25/night. For a 4-star hotel in Panama City, the cheapest rate recently found was C$ 58/night for this weekend.
How far ahead should you book a hotel in Panama City?
Save money by booking a hotel at least 70 days before your trip to Panama City. The lowest price found when booking 70 days ahead was C$ 21 per night.
Cheapest 5-star hotels in Panama City
Discover affordable 5-star hotels in Panama City that provide a quality experience without breaking the bank. 5-star hotels in Panama City can be found for as low as C$ 121 per night. Price data was last updated on 25 April 2025
These are the lowest-priced 5-star hotels our users have recently found in Panama City. Prices may vary based on dates selected and hotel location.
Show all 19 5-star hotels
Ave Eusebio Morales Esquina, Panama City, Panama
0.3 km from city centre
Free Wi-Fi
Parking
C$ 121
Avg. per night
C$ 140
Avg. per night
C$ 156
Avg. per night
083500257 Avenida Aquilino de la Guardia (C/ Aquilino de la Guardia) Panama City, Panama, Panama City, Panama
0.4 km from city centre
Free Wi-Fi
C$ 212
Avg. per night
Calle Punta Colon, Punta Pacifica, Panama City, Panama
2.2 km from city centre
Free Wi-Fi
C$ 224
Avg. per night
C$ 252
Avg. per night
C$ 272
Avg. per night
Balboa Ave. And Aquilino De La Guardia, Panama City, Panama
1.0 km from city centre
Free Wi-Fi
C$ 313
Avg. per night
Santa Maria Boulevard, Panama City, Panama
9.5 km from city centre
Free Wi-Fi
C$ 316
Avg. per night
47th Street & Uruguay Street, Panama City, Panama
0.8 km from city centre
Free Wi-Fi
C$ 349
Avg. per night
Calle Primera Oeste, Panama City, Panama
3.7 km from city centre
Free Wi-Fi
C$ 416
Avg. per night
Other star-rated hotels in Panama City
Hotels that are booked the most in each class receive the “Most popular” badge. Hotels with the “Best value” have the most attractive prices based on their popularity. Price data was last updated on 25 April 2025.
Not set on a 5-star hotel? We’ve got plenty of other options for you to choose from. These are the most popular and best value properties in Panama City based on hotel class.
4 stars
Km 7, Road To Veracruz, Panama City, Panama
C$ 289
Omar Torrijos Avenue, Panama City, Panama
C$ 91
Calle Jose I. Fabrega y Thais de Pons Panama City 581 PA, Panama City, Panama
C$ 99
Via Israel y Calle 71, San Francisco, Panama City, Panama
C$ 126
Calle 53 Marbella y Avenida 5a B Sur, Panama City, Panama
C$ 64
3 stars
El Cangrejo, Via Argentina, Calle Jose Fabregas Frente al Power Club y Diagonal al Restaurante 7 Mares, Panama City, Panama
C$ 65
Via Argentina Calle Principal, 49, Panama City, Panama
C$ 87
Av. Peru Calle 30, 25, Panama City, Panama
C$ 42
2 stars and under
Calle 1Era El Carmen- Casa # 32, Panama City, Panama
C$ 22
Other accommodations in Panama City
Find deals on places to stay in Panama City that are not hotels. These are just a few of the most popular hostels and vacation rentals in the area. Pricing information was last updated on 25 April 2025.
Looking for something less traditional for your stay? Find the perfect hostel or vacation rental for your trip in Panama City.
Show all 1,090 stays
Calle 42, Bella Vista Casa 33, Panama City, Panama
1.2 km from city centre
Free Wi-Fi
Parking
C$ 18
Avg. per night
Calle Margarita Vallarino, Casa 5b, Panama City, Panama
0.8 km from city centre
Free Wi-Fi
Parking
C$ 22
Avg. per night
083500257 Avenida Aquilino de la Guardia (C/ Aquilino de la Guardia) Panama City, Panama, Panama City, Panama
0.4 km from city centre
Free Wi-Fi
C$ 212
Avg. per night
C$ 140
Avg. per night
C$ 272
Avg. per night